N-Methyl-D-aspartic acid (NMDA)

N-methyl-d-aspartic acid review

Product name N-Methyl-D-aspartic acid
Synonyms NMDA, N-Methyl-D-aspartate, 6384-92-5, Methyl aspartic acid, N-Methyl aspartic acid, (R)-2-(Methylamino) succinic acid, NMDA agonist
CAS number 6384-92-5
Molecular formula C5H9NO4
Molecular weight 147.13
Specifications/purity >99 %
Appearance/color White crystalline solid powder
dosage 30-50mg per serving
benefits testosterone booster,muscle enhancement
Applied areas bodybuilding, sports nutrition,male enhancement,supplement


What is n-methyl-d-aspartic acid? N-methyl-d-aspartic acid is well-known in sports nutrition industry among bodybuilders and fitness lovers for its testosterone-boosting benefits. N-methyl-d-aspartic acid, abbreviated as NMDA, has several other names such as N-Methyl-D-aspartate, N-Methyl aspartic acid, (R)-2-(Methylamino) succinic acid, etc. N-methyl-d-aspartic acid has its unique identity-CAS number 6384-92-5.

When we talk about N-methyl-d-aspartic acid, you can never forget D-Aspartic acid (DAA). DAA is an excitatory amino acid while N-methyl-d-aspartic acid (NMDA) is deemed to be 100 times more potent than D-aspartic acid at stimulating the NMDA receptor. patrick Arnold is believe to be an active chemist inventor with DAA and NMDA.

Mechanism of action of n-methyl-d-aspartic acid

How does n-methyl-d-aspartic acid work? There is no much scientific information on this area, but we are to explain the acts in a simple way.
N-methyl-D-aspartic acid (NMDA) acts as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. As we know, glutamate is the excitatory neurotransmitter found in most synapses of the central nervous system, and pharmacologists made this analogue to activate a sub-type of glutamate receptors. Since there are multiple glutamate receptors, you can distinguish between them pharmacologically with different drugs, and NMDA is one of those drugs. In contrast to glutamate, NMDA binds to and regulates the NMDA receptor only, with no effect on other glutamate receptors.

D-Aspartic Acid breaks down into N-Methyl-D-Aspartic acid via a methyl transference reaction called NMDA Synthetase. N-Methyl-D-Aspartate then stimulates the Hypothalamus-Pituitary and testes to produce hormones. Therefore, if you take D-Aspartic Acid, it is the N-Methyl-D-Aspartic Acid, which gets there through conversion that actually does the work by increasing testosterone levels as well as growth hormone and luteinizing hormone.

N-methyl-d-aspartic acid vs d-aspartic acid

Both N-methyl-d-aspartic acid (NMDA) and d-aspartic acid (DAA) are popular in sports nutrition supplement formulas. As we mention before, NMDA is about 100 times potent than DAA in testosterone elevating. N-methyl-d-aspartic acid has the absolute most power and effectiveness possible in a natural, non-steroidal testosterone increaser.If you care more about the effects, choose NMDA; if you care more about cost itself, choose D-Aspartic acid. If you care both cost and effects, then you may use both in your formula for better performance and relatively lower cost. The below is a brief difference comparisons in dosing, and price concerns.

product name CAS number retail price recommended dosage Water Solubility
D-Aspartic Acid 1783-96-6 USD11/KG 2000mg to 3000mg 4.5g/L
N-Methyl-D-Aspartic Acid 6384-92-5 >USD800/KG 30mg to 50mg 25g/L


Benefits of taking n-methyl-d-aspartic acid supplements
N-methyl-d-aspartic acid is usually supplemented as a testosterone booster, testosterone enhancer, testosterone amplifier and thus good for increasing muscle strength, and other bodybuilding enhancements.

N-methyl-d-aspartic acid bodybuilding
Here when we talk about the relationship between N-methyl-d-aspartic acid and bodybuilding, in fact, we talk about the relation between testosterone and bodybuilding. Testosterone not only enhances athletic performance, builds mass muscles, but also sharpens memory, boosts libido, improves energy levels, and fat loss, etc, which are the main content of bodybuilding exercises. So keep it in mind that N-methyl-d-aspartic acid is to increase testosterone in the human bodies-male only. Women may don’t need testosterone.
N-methyl-d-aspartic acid side effects
N-methyl-d-aspartic acid is a very powerful testosterone enhancer and at a low dosage of 30 mg to 50mg is very effective for bodybuilders, and it is relative safe to be supplemented with other amino acids and herbal extracts such as brassaiopsis glomerulata extract. All the side effects rumors from bodybuilding forums are not true and no scientific reports on its serious side effects yet.

Where to buy bulk N-methyl-d-aspartic acid (NMDA)
N-methyl-d-aspartic acid (NMDA) or N-Methyl-D-aspartate is relatively less popular than D-Aspartic acid in sports supplements due to its high cost. There are no more than 3 real manufacturers of mass NMDA ingredient. The manufacturing capacity of N-methyl-d-aspartic acid is about 100 kgs per month, and no large stock is available.