Product nameSunifiram
Other namesDM-235, 1-benzoyl-4-propanoylpiperazine, 314728-8503 (CAS Number), CID 4223182 (PubChem), CHEMBL309176, C14H18N2O2, Sunifram
CAS number314728-85-3
Molecular FormulaC14H18N2O2 
Molecular Weight246.304
ApearanceWhite or almost white crystalline power

What is sunifiram?

Sunifiram (DM-235), according to Wikipedia, is an ampakine-like alkaloid derived from pipirezine which has nootropic effects 1000 times more potent than piracetam. A number of related compounds are known, including unifiram (DM-232). Sunifiram is often misspelled as Sunifram.

Sunifiram and Noopept

Many users and buyers associate sunifiram with noopept. Sunifiram is being compared to Noopept quite a bit because of their similar potency levels. Initial observations suggest that Sunifiram is better as a memory booster while Noopept might have an edge on increasing focus and alertness.

Mechanisms of action of sunifiram

How does sunifiram work? Preliminary studies suggest Sunifiram has two main mechanisms of action and in the below four steps:
1.Sunifiram activates AMPA-mediated neurotransmission.

2.It enhances LTP in a bell-shaped dose–response relationship. This enhancement by sunifiram is associated with an increase in phosphorylation of AMPAR through activation of protein kinase II (CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α(PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCα activation through Src kinase. Enhancement of PKCα activity triggers hippocampal LTP through CaMKII activation.

3.Sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation.PKC activation may be a common mechanism amongst cognition stimulating drugs from different chemical classes.

4.Sunifiram aids in the release of acetylcholine in the cerebral cortex.

Benefits of taking sunifiram supplements

Sunifiram, as a new and novel mind-enhancing nootropic, is highly effective at boosting memory function as well as attention span, learning, decision making and alertness. It is said to support energy, focus, and sharpened memory and cognitive performance.

Side effects of taking sunifiram supplements

Currently, there is not any known toxicity that is associated with Sunifiram.  Scientific research has also determined that animal test subjects have a tendency to build up a tolerance to Sunifiram on a rapid basis.  This process of tolerance is slowed down when Sunifiram was introduced sparingly as opposed to a consistent basis.

Additionally, scientific research on animal test subjects have yielded a minimal amount of side effects in relation to Sunifiram’s usage, and it has been theorized that the side effects that do exist relate to pain that is consistent with headaches.

Dosage of sunifiram supplements

Sunifiram Dosage and How to Take

Sunifiram is incredibly concentrated compared even to the strongest racetams like Pramiracetam. You will see positive effects from a dosage as small as 4 mg though many people typically take between 5-8 mg at a time. A Sunifiram dose of 10 mg is more likely to cause a stimulant effect similar to Adderall. Taking a 10 mg Sunifiram dosing is not toxic and not likely to cause serious negative side effects, however you may experience increased body temperature and perspiration. You should start with a half dose of 3 mg for your first week or so of taking this ampakine nootropic and then only increase the dosage if you feel comfortable.

Where to buy sunifiram?

Sunifiram is relatively new to the market and it is one of Herb Nutritionals Co., Ltd’s nootropics. Large bulk fine powder is available. And we ship to the countries all over the world. Couriers like Fedex, TNT, DHL, UPS, EMS, HKEMS, and SF are upon your choices. Two to three days from China to the rest of the world.