N-methyltyramine hcl
| Product name | N-Methyltyramine HCL |
| Synonyms | N-methyltyramine hydrochloride , NMT, 4-hydroxy-N-methylphenethylamine, N-methyl tyramine |
| CAS number | 13062-76-5 (hcl form), 370-98-9(NMT) |
| Molecular Formula | C9H13NO.HCl |
| Molecular weight | 187.67 |
| Appearance/color | Off white powder |
| Specification | 98% min |
| solubility | highly soluble in water and in ethanol |
| Benefits | Stimulant, fat burner |
| dosage | 50mg per serving |
| Application | Dietary supplements, sports nutrition |
| package | 25kg/drum |
What is N-methyltyramine?
N-Methyltyramine, the methylated version of L-Tyramine, is a popular sports nutrition stimulant used in many bodybuilding supplements. But it is often in the common salt form as N-Methyltyramine hcl or N-Methyltyramine hydrochloride. Many amino acids are more stable and absorbable in salt form, just like arginine base and arginine hcl, and N-methyltyramine is no exception. In addition to the effects and solubility, the unique CAS numbers are different. The cas # of N-methyltyramine is 370-98-9, while N-methyltyramine hcl is 13062-76-5.
N-methyltyramine, often abbreviated as NMT, has many other names, such as 4-hydroxy-N-methylphenethylamine, N-Methyl-Tyramine, 4-[2-(Methylamino)ethyl]phenol, Methyl-4-tyramine, NMT hcl, p-(2-Methylaminoethyl)phenol, etc. Of course, N-methyltyramine is the most common name known in supplement formulas to the bodybuilders and athletes.
Source of N-methyltyramine
There are many natural sources of N-methyltyramine from plants, such as barley, citrus aurantium, acacia rigidula leaf extract etc. citrus aurantium extract, also known as bitter orange (immature citrus fruits), is the best natural source of NMT with the highest content of N-methyltyramine while with the lowest cost. Moreover, there are more ingredients in citrus aurantium extract, including Synephrine, p-synephrine, diosmin, hesperidin, etc. N-Methyltyramine is converted to Synephrine by Dopamine β –hydroxylase, the detailed theory will be discussed in the mechanism of action sector.
Of cource, there is synthetic source of bulk N-methyltyramine powder from China, and it is easy to get and cheaper than the natural NMT. Of course, you are able to buy either form of N-methyltyramine from Herb Nutritionals Co., Ltd.
Mechanism of action of N-methyltyramine hcl
How does N-methyltyramine hcl work? To be simple, N-methyltyramine hcl may promote the release of norepinephrine, which supports energy levels; N-methyltyramine hcl may also promote the release of various neurotransmitters,supporting alertness and energy. NMT is a stimulant by boosting the effectiveness of phenylethylamine, Phenylethylamine is a natural mood altering ingredient. This ingredient may help some dieters feel better about dieting.
N-Methyltyramine may possess β2 adrenergic receptor activity, to improve plasma and myocardial cGMP and camping levels, continues to be observed to improve kidney and cerebral vascular resistance, and lacks a beta-hydroxyl or perhaps a beta-ketone group, implying it’s an indirect acting amine that releases cytoplasmic norepinephrine from supportive nerve being, much like tyramine. Vasoconstriction throughout exercise because of using NMT isn’t likely because throughout exercise, the α1-adrenergic receptors triggered through the norepinephrine launched by NMT could be selectively blocked by supportive nervous activity, permitting the β2-adrenergic receptors to dominate. Although it may have the symptoms of β1-adrenergic activity, there’s no observed action on amylase activity after administration of N-Methyltyramine.
N-Methyltyramine most significantly has got the qualities of the α2-adrenoceptor antagonist, although an inadequate one. α2 blockers considerably increase adrenergic, dopaminergic and serotonergic chemicals, increase blood insulin secretion and reduce bloodstream sugar levels. Using N-Methyltyramine also results in a rise in bloodstream pressure, relaxation from the ileum, a rise in pressure from the right atrium because of norepinephrine release, and a rise in rate of contraction in right atrium because of norepinephrine release.
Benefits of N-methyltyramine hcl
N-Methyltyramine has been popularly used in pre workout supplements as a stimultant like DMAA, caffeine, and fat burner. Stimulant and weight loss are its two main benefits.
N-Methyltyramine as Stimulant
N-Methyltyramine stimulate β1 adrenergic receptor thus then increases cardiac output – helps circulate oxygen and nutrients; more renin from the kidneys is released, thus also boost energy and performance in this way.
N-Methyltyramine as fat burner
N-Methyl-Tyramine is a Beta Receptor Agonist that can help you burn fat effectively and safely.
Many fat loss supplements focus on this beta receptor because its main function is lipolysis. NMT burns fat right off from your adipose tissue and improve your mental cognition as well.
Side effects of taking N-Methyltyramine supplements
N-Methyltyramine is relatively safe, and no severe adverse effects have been reported yet. N-Methyltyramine is a relatively weak stimulant, said to be only 1/40 potency of ephedrine, and doesn’t pose much risk of cardiovascular effects. However, the usage of N-Methyltyramine may lead to an increase in blood pressure, those who have Hypertension should avoid or take fewer dosage of NMT as the recommended dose.,
Dosage of taking N-Methyltyramine hcl supplements
There is no given dose for N-methyltyramine hcl ingredient. Many supplements use 50mg per serving in the sports nutrition supplements. It is recommend to stack N-methyltyramine hcl with other stimulants like caffeine, theobromine, hordenine hcl,etc.
Where to buy N-Methyltyramine hcl ingredient?
Bulk quantity N-Methyltyramine hcl powders are in stock from Herb Nutritionals Co., Ltd. Not only raw ingredients, capsules, tablets can also be customized according to the order. Detailed specification sheet, MSDS, production scale,quotation regarding hordenine is available via email or phone call.