Synephrine hcl

What is synephrine hcl?

Synephrine hcl is the short name of synephrine hydrochloride, both of which share the same unique CAS number of 5985-28-4. Generally speaking, synephrine is originally extracted from immature bitter orange (Citrus aurantium). We may discuss the difference between synephrine and synephrine hcl later.

synephrine hcl structure

Since the ban of ephedrine (the active ingredient in Ephedra plant) by the FDA in 2000 in the United States, dietary supplement manufacturers have been looking for a replacement for ephedrine. Luckily, synephrine founded in citrus extract has the similar structure to ephedrine, and is then marketed as a safe alternative to ephedrine as a weight loss and energy supplement ingredient. More and more weight loss products and pre workout supplements are using synephrine hcl in their supplement formulas, together with caffeine, herbal extracts, and other nutritional ingredients.

synephrine hcl vs ephedrine

Synephrine hcl VS synephrine base VS Methyl Synephrine

Many of our clients who buy bulk synephrine hcl powders from us are confused with these three derivative forms of synephrine. Many suppliers or retailers could not distinguish them correctly, and some product information on their websites is misleading buyers. We feel it is necessary to write something on it.

CAS differences

These three ingredients are three different chemicals and their formulas, structures are different. The cas number of synephrine hcl is 5985-28-4(C9H13NO2•HCl), CAS number of methyl synephrine is 365-26-4(C10H15NO2), while for synephrine base is 94-07-5(C9H13NO2).

Potency comparisons

According to our knowledge and feedback from end users, the potency differences are: methyl synephrine ＞ Synephrine hcl ＞Synephrine base, and of course, the price differs as well.

Source and specification comparisons

Both synephrine hcl and methyl synephrine are 98% min, 99% by way of chemical synthesis. While synephrine base is often naturally extracted from bitter orange, and the specifications is often in low concentrations. For example, synephrine 5%, synephrine 6%, synephrine 10%, synephrine 30%, and synephrine 50% are the most popular natural synephrine specs on the market. The cost is too high to concentrate natural 98% synephrine in the world. In this sense, any companies claiming to use nautral synephrine 98% are lying to our customers. Advantra Z® is the branded synephrine ingredient from nature, and their synephrine specifications are no more than 50%.

Synephrine hcl VS synephrine base

Many of you may ask, what’s the difference between synephrine hcl and synephrine base? We can only say that the hcl form of synephrine is stable while synephrine base is not. And you may notice that many products are in their salt form, such as arginine and arginine hcl, DMAA and DMAA hcl, etc. Salt form can be in high content of synephrine while the base form exists in low concentration.

Of course, the market players are looking for a more potent and effective synephrine for their supplements. Synephrine hcl can be regarded as the pharmaceutical grade synephrine and superior to the natural synephrine base since synephrine hcl is pure and its specification is stable at 99% from batch to batch, quite different from citrus aurantium derived synephrine which is difficult to accurately standardize an herbal ingredient.

Mechanism of action of synephrine hcl

Since synephrine hcl is comparable to ephedrine, we might consider the mechanism of action of ephedrine first. Ephedrine is really a sympathomimetic amine. The main mechanism of ephedrine’s action depends on its indirect stimulation from the adrenergic system by growing the activity of Noradrenaline in the post-synaptic α- and β-receptors. The existence of direct interactions with α-receptors is unlikely, but nonetheless questionable. L-Ephedrine, especially can mix the bloodstream brain barrier and functions as a CNS Stimulant much like Amphetamines but less pronounced, because it releases Dopamine and Noradrenaline within the Substantia nigra. However, based on the present study, synephrine or synephrine hcl doesn’t cross the blood brain barrier, and it is not potent as ephedrine.

Synephrine HCl is really a beta-3 adrenergic agonist., which stimulants the sympathetic central nervous system, also, at a cellular level leads to a release of norepinephrine and epinephrine by which you will find 5 different classes of receptors norepinephrine and epinephrine functions where are: alpha 1, alpha 2, beta 1, beta 2, and beta 3 with beta 3 and limited effects on beta 2 and alpha 2 studies have proven. Synephrine HCL enables the body to produce body fat from body fat cells to be burned for energy, which is called lipolysis and increases your resting metabolism (elevated metabolic process) and increases your body’s temperature which is called thermogenesis. This is capable because of the effect Synephrine HCL has on the beta 3 receptors.

Synephrine hcl Benefits

Synephrine hcl is well-known as a fat burner ingredient for weight loss purpose to the bodybuilders, athletes.

Synephrine HCL for weight loss

Synephrine HCL is said to have filled the space ephedrine left behind. The primary effect of Synephrine hcl is to slightly increase the metabolism and thereby help with weight loss. Synephrine hcl helps release the stored lipid cells into the bloodstream, and the metabolism, which is working at a faster rate than usual so it can burn off this stored energy, thus creating a loss of fat in the body.

Synephrine hydrochloride is often found in weight-loss formulas that involve many other compounds; often these products include powerful stimulants and herbs. Synephrine has the benefit of being able to lose weight without majorly increasing blood pressure or heart rate.

Similar to caffeine, synephrine supplies an energy boost, helps suppress appetite, and burns more calories even when exercise is not being undertaken. Many of those who take synephrine hcl combined with caffeine find this gives them the results they are looking for.

Synephrine hcl side effects

As a dietary supplement ingredient, synephrine HCL is likely safe for most grown-ups when used properly. However, there are some mild adverse effects among users who take too many synephrine hcl . Synephrine is a stimulant, so it is important to start at a low dosage to assess tolerance. Excessive synephrine HCL may cause rapid increases in blood pressure, cardiac arrhythmias, flushing of the skin, seating, restlessness, agitation, respiratory problems, dizziness, headaches, tremors, low blood sugar and blood sugar imbalances, stomach pain, nausea, and diarrhea, especially combined with other stimulants.

Synephrine hcl Dosage

Most synephrine-containing supplements available on the market recommend 120mg/day to weight loss benefits, despite the fact that scientists believe doses no more than 35 mg might be potent. Synephrine HCL works synergistically with caffeine, therefore if you are particularly sensitive to caffeine, it is best to start really small doses with synephrine if mixing with caffeine. To prevent toxicity, dosages shouldn’t approach or exceed the 1000mg/daily mark. Standard doses of Synephrine HCL are 50-100mg each day and 30-40 minutes before workout.

Where to buy bulk synephrine hcl powder?

Synephrine hcl is 100% purely synthetic ingredient, and bulk powder with package 5kg/bag, 25kg/drum are available. If you need to know the pricing and get a quote upon your detailed demand for synephrine hcl, please kindly send us an inquiry via email or direct phone call.