Bulk N-Oleoylethanolamide

Product name	N-Oleoylethanolamide
Synonyms	N-Oleoylethanolamine, Oleoylethanolamide, oleoylethanolamine, OEA, Oleoyl ethanol amide, (Z)-N-(2-Hydroxyethyl)octadec-9-enamide, N-Oleoyl Ethanolamine,NOE, N-(2-Hydroxyethyl)-9-octadecenamide, acid ceramidase inhibitor
Cas Number	111-58-0
Molecular Formula	C20H39NO2
Molecular Weight	325.54
Specifications	85%,98%,99%
Appearance/color	White to off-white powder
Solubility	Soluble in chloroform, ethanol, methanol, ethyl ether, DMSO
Benefits	Fat burner, nootropic, weight loss
Package	25kg/drum
Dosage	10mg/kg

What is N-Oleoylethanolamide?

N-Oleoylethanolamide normally appears in the short form of oleoylethanolamide, oleoylethanolamine, or simply OEA (Oleoyl ethanol amide) in N-oleoylethanolamide supplement. However, they are the same ingredient, referring to the molecular formula of C20H39NO2, with unique CAS number 111-58-0. The name of oleoylethanolamide is more popular and well-known than Oleoylethanolamine in the bodybuilding supplement industry, thus we will use the name of oleoylethanolamide more often in this article. The chemical structure of Oleoylethanolamide is as below:

N-oleoylethanolamide (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, and is the result of a combination of oleic acid and ethanolamine. However, the synthesis of both these components resulting in OEA is chiefly done by the upper part of the small intestine in the presence of rich fat content.
Oleoylethanolamide (OEA) is a fatty acid metabolite that is produced by the gut to signal to the brain the sensation of being full, thus to regulates appetite and healthy body fat. Similar to endocannabinoid anandamide, oleoylethanolamide OEA is a naturally occurring ethanolamide lipid that regulates feeding and body weight in vertebrates ranging from mice to pythons.

Sources of Oleoylethanolamide (OEA)

There are two sources of getting Oleoylethanolamide (OEA), one is from natural plants, and the other is by purely synthesized in the lab.
Achyranthes Aspera, native to India, China and many other Asian countries, is said to contain Oleoylethanolamide OEA. The problem of the natural-sourced Oleoylethanolamide is that there is only ratio extract is available, 15:1 is a popular spec, and it is not as potent as the clients or supplement manufacturers expect. Of course, it can be higher, but the cost will be extremely high, thus it is not so practical to manufacture natural Oleoylethanolamide OEA in bulk.

The mainstream source of Oleoylethanolamide is synthesized from oleic acid, served as a precursor of N-oleoyl-phosphatidylethanolamine, which is then cleaved by N-acyl-phosphatidylethanolamine-selective phospholipase D (PLD) to release Oleoylethanolamide OEA.

Mechanism of action of N-Oleoylethanolamide

Current data shows that oleoylethanolamide OEA induces satiety. How does this happen? What might be the mechanism of action of OEA on feeding suppression? It has been suggested that the anorexic effect caused by oleoylethanolamide OEA requires intact sensory vagal fibers as well as an activation of the nucleus of the solitary tract in the brainstem and the paraventricular nucleus in the hypothalamus. In this regard, animals with lesion in the peripheral sensory fibers failed to respond to the pharmacological administrations of OEA whereas surgical resection of the sympathetic celiac-superior mesenteric ganglion complex bocks feeding-induced OEA production in rat small-intestinal cells.

Additionally, it has been suggested that the food-intake suppression actions of OEA are mediated by the peroxisome proliferator-activated receptor-α（PPAR-α）, a nuclear receptor linked to the regulation of absorption, storage and utilization of dietary fat. Regarding this, the hypophagic effects of OEA are abolished in PPAR-α-null mice whereas food suppression is mimicked by PPAR-αagonists.

Overall, the above data suggest that OEA could be mediating anorexia via action of PPAR-αreceptors. However, further studies are needed to elucidate the mechanisms of action of PPAR-α in feeding.
The main role of oleoylethanolamide is to serve as a fat sensor, controlling fat intake and helping the metabolic network to adapt to the dietary fat load.

N-Oleoylethanolamide benefits

The key benefits of N-Oleoylethanolamide OEA include: function as an appetite suppressant, lose body fat, lower cholesterol levels, etc.

Oleoylethanolamide as an Appetite suppressant

Suppressing appetite and thus reducing the intake of food is an effective way to controlling both energy balance and body weight. Since appetite suppression is a major controlling point for energy (food) intake, managing appetite is crucial in controlling healthy body weight, especially when combined with health conscious lifestyle choices that include attention to proper food intake, dietary supplementation, and exercise.
Oleoylethanolamide helps regulate lipid metabolism, helps control hunger by sending appetite surpressant messages to the brain and has been shown to help lower both triglyceride and blood cholesterol levels.

Oleoylethanolamide for Body fat management

The obesity epidemic continues to spread throughout the world, and the search for efficient therapies to fight against obesity has become a priority for health. There are indeed some effective ingredients for fat burning, however, almost all of them are with different side effects to some extent, and some are even very serious. OEA is a safer peripheral mechanisms controlling appetite and energy expenditure.

Oleoylethanolamide bodybuilding

Nearly two-thirds of the world’s population now lives in countries where overweight and obesity are silent health killers. And everybody seeks health through bodybuilding in the gym. And OEA is increasingly popular to bodybuilders. In bodybuilding supplements fields, TTA (tetradecylthioacetic acid) is often synergistically used with oleoylethanolamide (OEA), both of which also helps to burn fat and decrease hunger. TTA may also be very promising among anti-fat supplements, because it appears to burn fat independent of exercise; preliminary results suggest that the body simply appears to “remove” fat from itself instead of needing to have it burned off with physical activity.

Oleoylethanolamide (OEA) reduces triglycerides and cholesterol, and, combined with a cannabinoid antagonist, blocks body weight gain and improves dyslipidaemia in animal models of obesity.

In addition, the systemic administration of oleoylethanolamide has been found to modulate glucose homeostasis, as well as both insulin release and insulin signaling in both hepatocytes and adipocytes.

N-Oleoylethanolamide side effects

Oleoylethanolamide OEA is relatively new to the supplement market, and no serious adverse effects have been reported. In daily life, oleoylethanolamide is a safe weight loss alternative, which is used to assess the extent of catabolism in the gastro-intestinal tract, helping to reduce fat without any detrimental uneanted effects.

N-Oleoylethanolamide dosage

There is no publicly recommended dosage for oleoylethanolamide since oleoylethanolamide supplements are still not so popular and at its early stage. However, there are some doses available on the market. On some supplement labels, 10mg/kg of body weight is the max daily suggested dose, equally to 100mg dose for 150 lb bodyweight; 145mg for 200 lb bodyweight while 180mg for individuals with 250 pounds.

Where to buy bulk N-Oleoylethanolamide powders?

Most of our oleoylethanolamide powder will be shipped by Fedex, DHL, or TNT express for bulk quantity below 500kg, with package 25kg/drum. If for large quantity over 1 metric ton, shipment by sea is the optimal choice. All documents like COA (certificate of analysis), MSDS, pricing of N-Oleoylethanolamide are available upon your inquiry.