Andrographis paniculata extract Andrographolide 50%,98%


Product name Andrographis paniculata extract Andrographolide 50%,98%
Latin Name andrographis paniculata
Synonyms king of bitters, Andrographis Extract, Kalmegh, Creat, Chuanxinlian, Yijianxi, Lanhelian, Indian Echinacea
Active ingredient Andrographolide
CAS number 5508-58-7
Molecular formula C20H30O5
Molecular weight 350.45
Specifications/purity 10%,20%,30%,50%, 98%(HPLC)
Appearance/color Off-white solid
Standard Chinese Pharmacopoeia 2010
Benefits upper respiratory tract infection, diarrhea, treat the common cold
dosage 2,000 – 6,000 mg
Applications Dietary supplements, drugs,medicines
Capacity 5 tons/month

What is andrographolide?

Andrographolide is the bitter bioactive ingredient standardized and extracted from the stem and leaves of the Andrographis paniculata plant, mainly native to China and India. China has the advantages of manufacturing higher quality andrographolide with specifications as 50%, 98%, etc. There are lower specifications available such as 8%, 10%, 20%, 30%, etc.

Andrographis paniculata has many other names, such as andrographolides, king of bitters, Andrographis Extract, Kalmegh in, Creat, Chuanxinlian, Yijianxi, Lanhelian, and Indian Echinacea. However, andrographis or andrographis extract is more popular appearing in dietary supplement labels and product names, while Andrographis paniculata is inside the detailed supplement facts or nutrition panel.

Generally Speaking, andrographolide or andrographis extract is not soluble in water, and andrographis supplements are therefore in the forms of capsules since powder is not believe to digest within water.

Based on Wikipedia, andrographolide can be used experimentally in various regions of research including cell signaling, immunomodulation, and stroke. In traditional Chinese herbal medications, andrographis is used to aid healthy digestive, cardiovascular, and urinary systems. In Sweden, andrographis has been utilized in excess of ten years being a primary plant for that winter months.

Chemical constituents of andrographis paniculata

Andrographis paniculata contains diterpenes, lactones, and flavonoids. Flavonoids mainly exist in the root, but also have been isolated from the leaves. The aerial parts contains alkanes, ketones, and aledehydes. The major constituents in andrographis are diterpene lactones known as andrographolides. Four lactones Chuaxinlian A (deoxyandrographolide), B (andrographolide), C (neoandrographolide) and D(14-deoxy-11, 12-didehydroandrographolide) were isolated from the aerial parts. The leaf and stem extracts were assayed for the presence of glycosides, flavonoids, gums, steroids, terpenoids, tannins, saponins and phenolic compounds. The ethanol, acetone, methanol, petroleum ether and chloroform extracts of Kalmegh were screened for the presence of secondary metabolites.

Mechanism of action of andrographolide

How does andrographolide work? There are no detailed modes of actions of andrographolide at present.

Andrographolide has been shown to be responsible for the herb’s inflammatory modulating actions, including the reduction of cytokine and peritoneal deposition of neutrophils, and modulation of lung inflammation in vivo.

Scientists have discovered that andrographolide helps to boost the immune system by stimulating the body’s production of antibodies and macrophages, which are large white blood cells that scavenge harmful microorganisms. It is taken for both the prevention and treatment of the common cold.

Researchers believe that andrographolide may stimulate the immune system, and improve the blood cell counts in people with HIV, and help with allergies.

Andrographolides have potent anti-inflammatory and antimalarial qualities. Additionally, it has antimicrobial qualities, meaning it can benefit to battle off and stop infections from dangerous microbes for example infections, fungi and bacteria. Additionally, andrographis is really a effective antioxidant also it can assistance to prevent toxin caused harm to your cells and DNA.

Benefits of andrographolide

andrographolide can be used both in pharmaceutical and nutritional supplements formulations because of its laxative, antipyretic, antiperiodic, anti-inflammatory , expectorant, anthelmintic, digestive and stomachic qualities. It’s also employed for general debility, dyspepsia, stomach problems and dysentery among grown ups.
Andrographolide and Immune Support
Andrographis is among the most broadly used botanicals for marketing healthy respiration against Respiratory system Infections. Andrographis combines this key botanical using the primary European and United States herbal treatments including echinacea, goldenseal, garlic clove, and olive leaf for supporting winter wellness and broad spectrum immune support.

Andrographolide and cold and Flu
It might help decrease the severity of cold symptoms including sleeplessness, fever, nasal drainage and sore throat.

Taking Andrographis may aid to lessen the seriousness of your symptoms from the common cold. Andrographis extract was indeed more beneficial than placebo in managing the symptoms associated with acute respiratory infections, including the common cold and flu. A specified Andrographis concoction taken at the dosage of 6 grams daily for one week was equally effective as acetaminophen in reducing fever and sore throat.
Andrographolide side effects
Andrographolide is generally safe for most adults when used short-term, and there are no serious adverse effects of Andrographolide on the markets.

Some people develop intestinal upset when taking andrographis. If this happens, lessen the amount taken or go with foods. Headache, fatigue, a bitter/metallic taste, and elevated liver enzymes were reported in a single trial with Aids-infected people taking high doses of isolated andrographolides.

When utilized in high doses or lengthy-term, Andrographis could potentially cause inflamed lymph glands, serious allergic responses, elevations of liver enzymes, along with other unwanted effects.

Dosage of andrographolide
Andrographis is usually obtainable in capsules with dried plant or as standardized extracts (that contains 11.2 mg andrographolides per 200 mg of extract). For dried plant, 500-3,000 mg is taken three occasions each day. In clinical tests, 100 mg of the standardized extract were taken two occasions each day to deal with the most popular cold. For heartburn, andrographis might be taken like a tea. Use 1 teaspoon (5 grams) from the plant for every cup (250 ml) of warm water. Permit the mixture to face for 10-fifteen minutes before consuming (sip before foods).
Where to buy high quality andrographis raw ingredient?
Andrographis paniculata extract, with active compound as andrographolide, is Herb Nutritionals Co., ltd’s common stock readily available all year around. If you want to know the pricing quotation, certificate of analysis (COA), please don’t hesitate to contact us via phone or email.