Huperzine A
| Product name | Huperzia serrata leaf extract |
| Latin Name | Huperzia serrata |
| Synonyms | HupA , Toothed Clubmoss, Quian Ceng Ta, Chinese club moss, ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule, selagine |
| Part used | leaf or aerial parts |
| Active ingredient | Huperzine A |
| CAS number | 102518-79-6 |
| Molecular formula | C15H18N2O |
| Molecular weight | 242.32 |
| Specifications | 1%,5%,99% |
| Appearance/color | Brown to white powder |
| Benefits | Memory Enhancement, Alzheimer's Disease,nootropics, |
| Dosage | 50-200mcg daily |
| Applications | Dietary supplements, pharmaceuticals, medicines, drugs |
What is Huperzine A?
Huperzine A is an active component of alkaloids obtained from huperzia serrata, a plant unique to China, and might not find elsewhere in the rest of the world. Huperzia serrata, also referred to Chinese club moss, HupA,Qian ceng ta or Quian Ceng Ta in Chinese language, is clinically determined as a member of the family huperziaceae, which is associated to the huperzia genus. Huperzine A has long been utilized in ancient China to take care of fever, inflammation and sharpen memory. Huperzine A is known to the Westerns for its potent effect for treatment of Alzheimer’s disease.
Sold as a nutritional supplement, huperzine A can be used alone, or together wither other herbal extracts. In the United States it is from the commercial perspective available as being a food supplement, and also has been approved by the FDA as a treatment for AD or other cognition disorders.
Botanical sources of Huperzine A
Huperzine A was isolated in 1986 the very first time from huperzia serrata in China. Other varieties of huperziaceae family have also been identified to possess Huperzine A, such as lycopodiaceae and selaginella.
In huperzia serrata, there is below 0.02% by weight content of huperzine A. However, the rapid growing demand and high cost of the raw material areraising the pressure on the natural environments and the huperzia zerrata has become a threatened plant in China as a result of the over-exploitation and habitat fragmentation.What’s more, besides no being particularly abundant, these plants also grow extremely slowly. Large numbers of Chinese manufacturers, suppliers and export companies are developing chemical synthesis for the 99% huperzine A, and some even synthesize the 1% huperzine A already. We have synthetic huperzine A 99% and it is very competitive on the dietary supplement markets. The synthetic Huperzine-A is said to have the same bioequivalence to the natural version.
Chemical constitutions of huperzia serrata extract
Several lycopodium alkaloids with diverse chemical structures have already been isolated from the huperzia serrata and they are still inspiring several research groups to discover new alkaloid compounds. The majority of lycopodium alkaloids are liposoluble and they are distinguished into four major structural classes- fawcettimine-type, lycodine-type, lycopodine-type, and a couple of miscellaneous-type compounds.
The chemical ingredients of huperzia serrata have been reviewed, however, the major researches consentrate on huperzine A, a lycodine alkaloid. Three additional classes of alkaloids (lycopodine, fawcettimine and miscellaneous) and also triterpenes, flavones, and phenolic acid are additionally found.
Chemically, huperzine A is 9-amino-13-ethylidene-11-methyl-4-azatricylo tridec-3, 6,11-trien-5-one. The most part of alkaloid compounds that inhibit the AChEenzyme fall into the lycodine-type class and comprise Huperzine A, 6β-hydroxyHupA, huperzine B,N -meth-ylhuperzine B and huperzinine.
Specifications of Huperzine A
There are many popular specifications of huperzine A, such as huperzine A 1%, 5%, 98%, 99%. Other low specifications such 20% can be customized accodrding to your demand.
Mechanism of action of Huperzine A
How does huperzine A work? Multiple proposed mechanisms of action for huperzine A are obtainable in the literature. It is a selective AChE inhibitor. It also been proved to have antioxidant and neuroprotective properties counteracting glutamate-induced toxicity, possibly by interacting with NMDA receptors
Huperzine A is recognized to enhance memory storage, consolidation and retrieval. Huperzine A is a Cholinesterase inhibitor which means that it boosts amount of acetylcholine in the brain. This chemical is utilized as an important transmitter between neurons, renowned for sending signals linked to the encoding of memories. The acetylcholine neurotransmitter is influenced by Huperzine A in the same manner as FDA approved medications for Alzheimer’s. The availability of Huperzine A, however, is much easier to come by and it is significantly cheaper. Taking Huperzine A might be beneficial at preventing cognitive decline, senile dementia and disorders such as Alzheimer’s.
huperzine A has been found to function as a cholinesterase inhibitor, a sort of medicine designed to avoid the breakdown of acetylcholine (a chemical essential for learning and memory).
Huperzine A benefits
Huperzine A is the subject of ongoing research investigating its potential to support cognitive functions and enhance memory. Our new Maximum Strength Huperzine A gives you four times the brain-nourishing power of our 50 mcg formula.
Treatment for Alzheimer’s disease
Alzheimer’s disease (AD) is the most typical root cause of severe mental deterioration (dementia) in the elderly. It has been estimated that 30% to 50% of individuals over 85 years end up having this problem. Its cause is not known.
There are two natural remedies for Alzheimer’s disease with significant scientific evidence behind them: ginkgo and phosphatidylserine .Huperzine A and vinpocetine , while more like drugs than herbal or homeopathic remedies, may also improve mental function in folks with dementia.
Huperzine a as a nootropic
Huperzine A has long been claimed as among the world’s best naturally sourced cognitive enhancers.
Huperzine A is a well-known ingredient in nootropic stacks and it is also thought to be one of the most impressive natural nootropics alone. Huperzine A offers many health benefits for people who desire to enhance theirmental ability. It is selected both by students who are seeking to facilitate better learning and among adults who would like to maintain their memory working at the best level.
As a cognitive enhancer, the nootropic outcomes of Huperzine A is due to its capability to inhibit an enzyme that destroys acetylcholine, an significant neurotransmitter in the brain which is considered to be in charge of most of the cognitive processes.
As a nootropic, Huperzine A is far more commonly stacked jointly with other nootropic agents. It is believed to complement the effects of Alpha GPC, which accelerates the generation of acetylcholine in the brain.
Huperzine A side effects
Negative effects from Wikipeida demonstrate that Huperzine A may typical to mild cholinergic adverse effects, for example, nausea, vomiting and diarrhea.
The use of huperzine A in pregnancy and lactation is not recommended simply because of the insufficient safety data. The majority of people who consume Huperzine A do not experience side effects, but there have been cases of negative reactions. One common adverse reaction is strange dreams and lucid dreaming. You may have better memory of your nighttime adventures which may be unpleasant especially when your dreams are more like nightmares.
Huperzine a dosage
Huperzine A is a highly potent ingredient, alone or stacked with other herbal ingredients. The dosing may vary for different purposes, such for Alzheimer’s disease, for memory support for students or bodybuilding fans for their prework out. In addition, the purity or assay of huperzine A may affect the dose. However, 1% huperzine A is more popular on the market and a recommended dose of only 100 to 200 micrograms (mcg) twice a day for age-related memory loss.
Where to buy Huperzine A raw ingredient?
Huperzine A, along Alpha GPC, Bacopa monnieri Extract, Vinpocetine, are our most competitive nootropic ingredients for the brain enhancers. Formal documents like certificate of analysis (COA), MSDS, prcing are available for your request.