coluracetam 99%

What is coluracetam?

Following piracetam, aniracetam, oxiracetam,pramiracetam, phenylpiracetam and nefiracetam, coluracetam is one of the newest ingredients in the racetam family. As far as potency is concerned, coluracetam is among the strongest nootropics and maybe stronger than noopept.

Coluracetam, with CAS 135463-81-9, is also known as BCI-540 and MKC-231. Coluracetam was invented in Japan and only first registered in 2005 by the Mitsubishi Tanabe Pharmaceutical Corporation, and then its patent has been transfer to BrainCells Inc. Coluracetam is a brain supplement for cognitive enhancer, memory improvement as well as also treats Major Depressive Disorder(MDD) and also anxiety problems. The coluracetam formula structure is as below:

Coluracetam formula

Mechanism of action of coluracetam

How does coluracetam work? The mechanism of coluracetam is quite different from other racetam compounds like piracetam or aniracetam. There are two well-defined mechanisms of action for coluracetam: one is high-affinity choline uptake and the other is AMPA potentiation.

high-affinity choline uptake(HACU)

Like most racetam compounds, coluracetam increases choline uptake, but it also increases uptake in damaged neurons. Choline uptake plays a crucial role in the acetylcholine synthesis process in the brain by acting as a rate-limiter. This rate-limiting step allows the brain to convert choline into acetylcholine in the neuron, and by increasing the high-affinity choline uptake the brain is more readily able to convert choline to acetylcholine; by increasing the ability to convert choline to Acetylcholine, should in theory improve attention, memory, and wakefulness in humans. without acetylcholine, it would be impossible to move our muscles or even be able to remember simple facts.

AMPA potentiation

Research shows that Coluracetam also improves α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) potentiation, a receptor for glutamate that aids in synaptic transmission in the central nervous system process that boosts alertness and cognitive functions.

Benefits of coluracetam

Coluracetam is proved to be effective to improve cognitive functions in memory and learning, depression, anxiety and eyesight.

Memory and Learning

Probably the most exciting advantages of Coluracetam is long term enhancements in memory-impaired people.
Like the majority of racetam s, coluracetam will work for the brain health. Research carried out by BrainCells Corporation, demonstrated a memory improvement in rats who have been given substance AF64A (a neuron-specific neurotoxin) for 8 days together with Coluracetam in 3mg doses. These rats were subjected to the standardized Morris Water Maze to mark their capability to cope with it, as well as as much as 72 hrs following the last 8mg dose, they are still capable to go through the maize. Another key finding of the study could be that the outcome was still apparent three days following the last dose, despite the fact that the serum power of Coluracetam was minimal.

Coluracetam is proven to enhance cognitive function and memory in rats, and theoretically, exactly the same answers are expected in people.

Depression and Anxiety

BrainCells Corporation, discovered that a dose of 240mg (split up into three daily doses of 80mg) was helpful in dealing with depressive disorder co-morbid with generalized anxiety disorders.However, the variations were most pronounced in individuals who didn’t find relief in making use of standard antidepressants. After one dosing, there have been no noticeable variations, but after 2 doses at 80mg, 36% had enhanced scores throughout a depression assessment test.

Coluracetam and Eyesight

Coluracetam is also associated with optic benefits,for instance, enhanced color vision, recognition and vividness. Although there’s no conclusive evidence to support the mechanisms behind this benefit, experts believe that Coluracetam works in part of your brain that runs visual processes.

Coluracetam side effects

Since coluracetam is a comparatively new comer to the marketplace, there’s very little information available regarding the toxicity of the nootropics. However, it appears that it’s relatively safe since the mechanisms of action and structure are similar with other racetam supplements. BrainCells, the company who now have patents and saying with this ingredient, says that they didn’t observe any negative effects when subjects used Coluracetam dosages as much as 80 mg three occasions each day.

Coluracetam dosage

There isn’t much information regarding the dosing of coluracetam. Coluracetam is a rather fast acting nootropic that may be detected in neural tissue within half an hour of ingestion. Recommended dosage is 48-480mcg/kg, ie 3.2-32.7mg for a 200lb person. You may then increase your dosage gradually after familiar to the supplement.

However, the majority of the reports say that the dose of roughly 200 mg each day could be useful to an average joe. Obviously, the dosage might also rely on your causes of using the supplement to begin with. For individuals struggling with major despression symptoms taking on to 100 mg three occasions daily has proven to work.

Where to buy bulk coluracetam?

Coluracetam is new, and not so many bulk coluracetam suppliers on the market. However, large quantity coluracetam is available from Herb Nutritionals Co., Ltd all year around. Formal documents like certificate of analysis, specification sheet, MSDS, pricing of coluracetam are glad to sent to you for your reference.