Galantamine Hydrobromide 99%

Product name	Galanthamine Hydrobromide
Source origin	Lycoris radiata (LHer.) Herb.
synonyms	Galantamine HBr, RAZADYNE ER, Reminyl , Nivalin, Lycoremine, (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
CAS number	1953-04-4, 357-70-0 (free base)
Molecular formula	C17H21NO3 •HBr
Molecular weight	368.27
Specifications	98%,99%
Solubility	sparingly soluble in water
Appearance/color	white to almost white powder
Package	1kg/aluminum foil bag with inner plastic bag
Benefits	dementia caused by Alzheimer’s Disease, nootropics
Applications	lucid dreaming pill, Lucid Dreaming Supplement

What is galantamine?

Galantamine, also known as galanthamine, is a tertiary alkaloid, originally extracted from the bulb of galanthus woronowi, and then identified in saussurea involucrata, Narcissus L, Lycoris and species of amaryllidaceae plants, etc. According to wikipeida, galantamine is a competitive and reversible acetylcholinesterase inhibitor and modulates the neuronal nicotinic acetylcholine receptor. In other words, galantamine hydrobromide is for the treatment of patients with mild or moderate Alzheimer’s disease. For the usage in medicine or nootropics, galantamine is always in the form of Galantamine Hydrobromide.

Galantamine Hydrobromide is often abbreviated as Galantamine HBr with unique CAS number 1953-04-4. For galantamine base, the cas # is 357-70-0. If not specified, galantamine here refers to galantamine hydrobromide. The galantamine structure is as below:

Source of Galantamine Hydrobromide

There are two main sources, one is from nature, the other is from labs via synthesis.

Galantamine Hydrobromide from nature

Galantamine Hydrobromide is able to get from the bulb of leucojum aestivum, the content is around 0.1% to 2% on dry basis. While Galantamine Hydrobromide has higher content up to 7.4% in phaedranassa negistrophylla, another name of Lycoris radiata plant. However, these plants are from key precious resources and protected by the government. There are 20 lycoris species in the world, and 16 species in China, locating along the middle and lower reaches of the Yangtze River. The raw plants nowadays are cultivated and bulk quantities are available. Lycoris radiata is the most popular natural source for the extraction of Galantamine Hydrobromide.

Galantamine Hydrobromide from synthesis

Racemized Galantamine Hydrobromide was first synthesized by Barton in 1962. After that, many new routes have been developed and new methods are available for galantamine mass production.

Mechanism of action of galantamine hydrobromide

So how exactly does galantamine hydrobromide work? Although the act of cognitive impairment in Alzheimer’s (AD) isn’t fully understood, it’s been reported that acetylcholine-creating nerves degenerate within the brains of patients with Alzheimer’s. The degree of this cholinergic loss continues to be correlated with amount of cognitive impairment and density of amyloid plaques (a neuropathological hallmark of Alzheimer’s).
Galantamine hydrobromide binds electrostatically towards the enzyme active site of cholinesterase. Binding is reversible, as a result it functions as a competitive reversible inhibitor of cholinesterase and extends the hydrolysis of endogenous acetylcholine, therefore growing its accumulation and extending and potentiating its effects, that are expressed in intensified and prolonged mediation at the amount of cholinergic postsynaptic membrane. Galantamine hydrobromide has been discovered to exert direct impact on some CNS structures with cholinergic nerves. Additionally, it functions in CNS by reflex path, potentiating afferent impulses from some peripheral reflexogenic areas..

Benefits of Galantamine Hydrobromide

Galantamine hydrobromide is proved to treat mild to moderate dementia from the Alzheimer’s. Galantamine also has been utilized regularly throughout Europeto treat various conditions such as myasthenia, myopathy, and various kinds of physical or motor dysfunctions. Galantamine also remains an extremely popular Nootropic supplement for memory enhancements and improved intellectual capacities.

Galantamine as a nootropic

The rise of Acetylcholine is crucial to these beneficial effects ever since the neurotransmitter is believed to play a key role in memory and learning. Many buyers will feel a boost in memory formation, an all-around elevated learning capacity, enhanced attention span (perhaps even extended), and focus. The supplement also offered a variety of health advantages in associated with promoting deep high-quality sleep. Galantamine reviews often cite having the ability to not just go to sleep faster but additionally relax more soundly and awake more rejuvenated, which may be helpful for people struggling with insomnia or any other sleep problems.

Galantamine and lucid dreams

Lucid dream is dream where the person recognizes that they are in dream and is actually conscious of this. Even if the ultimate result isn’t a lucid dream, Galantamine might lead to making dreams clearer and much more memorable. Tihsi is because that elevated acetylcholine levels are able to improve the ideal activity while increasing REM sleep duration.

By obstructing the unnecessary firing of some nerves, Galantamine hydrochloride helps make feelings of elevated relaxation and much more workable responses to stimulus of all types, which leads to a simpler transition into sleep when preferred. The upkeep of high amounts of Acetylcholine results in considerably longer periods of REM sleep, time throughout which lucid fantasizing becomes possible.

REM sleep can also be considered to boost creativeness, enhance memory, and lower stress, aggression, and depression, though it’s not fully realized why. Without any significant unwanted effects known, Galantamine provides simpler accessibility vital relaxation that everybody needs each day.

Galantamine Hydrobromide side effects

The side effects of galantamine hydrochloride may be very uncomfortable, and mainly contain vomiting(throwing up) and nausea(sickness). Modifying the patient’s diet might help mitigate these effects. The seriousness of the adverse effects and also the small amount of improvement has brought some doctors to summarize that anticholinesterase treatments are not warranted. Current types of pathology concentrate on the beta amyloid plaques that form within the brain.

Galantamine Hydrobromide dosage

The suggested beginning dosage of galantamine hydrobromide extended-release capsules is 8 mg/day. The dosage ought to be elevated towards the initial maintenance dose of 16 mg/next day of no less than four weeks. An additional increase to 24 mg/day ought to be attempted after no less than 4 weeks at 16 mg/day. Dosage increases should depend on assessment of clinical benefit and tolerability from the previous dosing.
It is crucial that the patient be began in the lowest dose of galantamine hydrobromide after which has got the amount elevated very progressively. The medication is only designed to modify the signs and symptoms and doesn’t decrease the advancement of the condition. It might take as much as three several weeks to determine any effect. People can vary in the way they are influenced by this drug.

Where to buy bulk Galantamine Hydrobromide?

Galantamine Hydrobromide is a Chinese-based ingredient for treatment of Alzheimer’s disease, and Herb Nutritionals Co., Ltd is one of the leading raw material manufacturers of Galantamine Hydrobromide. If you need to know the pricing and documents like certificate of analysis (COA), MSDS, specification sheets, manufacturing process, please do not hesitate to write to us. We will reply to you within 12 hours.