sulbutiamine is a nootropic good for mood and memory enhancement, fight against fatigue.

Sulbutiamine 99%

Product name Sulbutiamine
Synonyms Arcalion, isobutyryl thiamine disulfide, bisibuthiamine, enerion, youvitan
CAS number 3286-46-2
Molecular formula C32H46N8O6S2
Molecular weight 702.89
Specifications 99%
Appearance/color White to off-white crystalline powder
solubility Fat soluble (thiamine is water soluble)
Benefits Enhance memory,mood,fight fatigue
Applications Nootropics, supplements, medicines
Half Life 5 hours
Package 25kg/drum
Dosage 400 mg

What is sulbutiamine?

Sulbutiamine, also popularly known as arcalion, bisibuthiamine, is a white to off-white crystalline powder, mainly 99% above. Sulbutiamine has the unique CAS number of 3286-46-2. Popularly used in dietary supplements as a nootropic ingredient, sulbutiamine is beneficial to memory improvement, learning, focus, and cognitive support. Due to the recent raw material cost rise for vitamine B1 in June and July, the price for sulbutiamine rises dramatically. If you want to know the exact pricing for bulk sulbutiamine powder, please email us in the contact page.

Sulbutiamine formula

Sulbutiamine formula

Sulbutiamine VS Thiamine

According to Wikipedia, sulbutiamine is a synthetic derivative of thiamine, and much better than that. Sulbutiamine is superior to thiamine, or known as an enhanced version of vitamine B1. Thiamine has very poor bioavailability and could not soluble within the human body. While sulbutiamine is lipophilic (or Fat soluble), and crosses the blood-brian barrier more readily and reaches the brain more quickly than thiamine. In one word, the greatest difference between sulbutiamine and thiamine is the absorption rate. Of course, the dosage of sulbutiamine is less than thiamine. Thiamine is absorbed in the digestive tract at a poor rate that’s frequently reduced by hindrances like folic deficiency. Getting greater levels of Thiamine within the digestive system may also reduce this absorption rate even further.

Mechanism of action of sulbutiamine

How does sulbutiamine work? We may compare it with thiamine. Thiamine is utilized within the biosynthesis of acetylcholine (Ach) and Gamma aminobutyric acid (gamma aminobutyric acidity). Acetylcholine is the most common neurotransmitter situated both in the nervous system (CNS) and also the peripheral central nervous system(PNS). The metabolic process of sulbutiamine within the brain results in a rise in the amount of thiamine and thiamine phosphate esters. Sulbutiamine is thought to possess effects around the cholinergic, glutamatergic and dopamine systems which lead to its nootropic benefits.
Sulbutiamine and cholinergic
In animal study, sulbutiamine has long been proven to boost choline uptake within the hippocampus by 10% via HACU(High Affinity Choline Uptake). Sulbutiamine enhances the part from the nervous system by growing amounts of key natural chemical acetylcholine and fortifies “myelin sheaths”, the protective covers in our nerves.
Sulbutiamine and Dopaminergic
Dopamine receptors are prominent within the nervous system and have the effect of many important nerve processes for example memory, learning and cognition. Dopamine is really a natural chemical that enables intercellular communication. Dopamine plays a part in feelings of happiness as well as in the reward system from the brain. Greater amounts of dopamine activity can promote enhanced focus, concentration and motivation. Using dopaminergic supplements can enhance your mood, place you in an optimistic frame of mind and combat certain signs and symptoms of depression.
Sulbutiamine has dopaminergic features, but utilizes a mechanism of action not the same as other dopamine-improving ingredients. Sulbutiamine really cuts down on the discharge of dopamine within the prefrontal cortex. When dopamine levels are reduced, the quantity of dopamine receptors increases as a part of a compensatory system. Dopamine receptor levels are associated with rates and concentration. As a result, because Sulbutiamine reduces dopamine levels and increases the quantity of dopamine receptors available, it can make your body more responsive to any dopamine releases that could occur. Because of this, some students utilise it when studying to improve their learning and productivity.

Simultaneously, Sulbutiamine positively affects our mood by raising dopamine levels. The natural chemical dopamine plays a vital role within the brain’s pleasure-reward system as well as improves our capability to focus.

Benefits of taking sulbutiamine supplement

Probably the most well-known benefit that sulbutiamine brings is its amazing capability to enhance the memory. Additionally, sulbutiamine may also be advantageous to mood, cognition, fatigue and anxiety.

Sulbutiamine & Memory

Sulbutiamine has an effect on dopamine, glutamate, and acetylcholine levels in the brain. Many of these neurotransmitters are greatly accountable for memory formation – especially acetylcholine. Acetylcholine facilitates the absorption, storage, and recall of new information inside the brain.
Those who have taken sulbutiamine regularly have noted reasonable rise in remarkable ability to take in and retain information. Quite simply, they’ve observed a noticable improvement both in their short and long-term memory abilities.
Furthermore, sulbutiamine encourages end users to concentrate their focus on specific tasks, while concurrently improving remarkable ability to see and react proficiently to occasions which are occurring around them. Because of this, many customers have reported that sulbutiamine is a superb study aid.


If you’re looking for supplements for mood enhancement, sulbutiamine might be one of the nootropics you should think about. Sulbutiamine appears to possess some valuable anti-depressant effects, especially when it involves reducing anxiety. This might be because of the results subutiamine has on dopamine and D1 receptors. The transmission problems of dopamine are frequently triggered by mood disorders and anxiety, which would explain the potential mood improvement effects sulbutiamine has on individuals who go ahead and take supplement. Research has also proven that sulbutiamine has demonstrated the possiblity to lessen the behavior hang-ups in many people that are most generally observed in those who have anxiety or mood disorders.

Sulbutiamine and Fatigue

sulbutiamine fatigue

sulbutiamine fatigue

If you look back at the history of sulbutiamine, you may find from Wikipedia that Sulbutiamine is the only ingredient used to treat asthenia,a condition of chronic fatigue that is cerebral and not neuromuscular in origin.

As a dietary supplement, exercise lovers and sports athletes make use of it to fight fatigue without a medical prescription. Some individuals experience a mild stimulatory effect not having the common side effects of amphetamine. This might be simply because that sulbutiamine only affects dopamine and not other catecholamines. Some patients with Parkinson’s disease and schizophrenia who experience intellectual asthenia find relief by taking sulbutiamine supplement.

Recent studies show that sulbutiamine is effective to treat psychogenic erectile dysfunction. More benefits of sulbutiamine are to be proved by scientists and chemists yet.

Sulbutiamine side effects

Sulbutiamine is sold as a dietary supplement or nootropics, and no serious adverse effects have been reported. However, individuals who take sulbutiamine may experience side effects such as moderate agitation or allergic skin rash. This generally is a consequence of taking an abnormally high dose. It’s suggested to discontinue use if going through unwanted effects.

Sulbutiamine Dosage

Dosage for sulbutiamine is recommended at 400mg to1000 mg daily. Some supplement brands suggest 12.5 mg per kilogram of bodyweight. Others sulbutiamine products mention not to take more than 600 mg daily. The general recommended Sulbutiamine dosage is about 600 mg each day, take three doses of 200 mg, one in the morning,one in the mid-day and the other at night. It’s available in pills, capsules and powder form, generally in doses 200 mg each. It might be taken without or with food, although taking sulbutiamine with a meal is suggested since sulbutiamine is body fat soluble.

Where to buy bulk sulbutiamine powder?

Herb Nutritionals Co., Ltd is a China-based manufacturer of sulbutiamine. Sulbutiamine is one of our key products, with capacity 1500kg/month. 99% is the main specification. At present, we only offer sulbutiamine raw powders to supplement manufacturers, distributors, and trading companies.