Nicotinamide Riboside

Product name	Nicotinamide Riboside (NR)
Synonyms	NAD+ Precursor, Niagen,NR, Nicotinamide ribonucleoside, nicotinamide-beta-riboside
CAS number	1341-23-7
Molecular Formula	C11H15N2O5+
Molecular weight	255.25
Specifications	99%
Appearance/color	White powder
Benefits	Anti-aging, weight loss, for endurance, energy
Dosage	250mg per serving twice a day
Applications	Dietary supplement, bodybuilding,sports nutrition

What is nicotinamide riboside?

Nicotinamide riboside is a break-through ingredient in dietary supplement industry to fight obesity and offer energy for endurance and healthy aging. According to Wikipedia, nicotinamide riboside is a NAD+ precursor, falling into the category of vitamin B3.

Nicotinamide riboside, often abbreviated as NR, has many other names, such as 1-(β-D-Ribofuranosyl)nicotinamide; N-Ribosylnicotinamide, NAD precursor, Nicotinamide ribonucleoside, nicotinamide-beta-riboside, Nicotinamide adenine dinucleotide precursor,Niagen, etc. NIAGEN from ChromaDex, Inc is the first commercially available form of nicotinamide riboside (NR).However, CAS 1341-23-7 is the unique identity of nicotinamide riboside, with the molecular formula as below:

Nicotinamide Riboside Food Sources

Trace amounts of nicotinamide riboside are found in a few foods, such as milk, beer, but no food provides significant levels of nicotinamide riboside. However, at the moment, we can’t even measure its concentration in milk or other food sources. Therefore, bulk nicotinamide riboside is not available from natural sources. This dilemma has been solved with the development of a manufacturing process that can now efficiently provide NR in quantities sufficient for widespread commercial use. All those nicotinamide riboside are synthetic or fermented in labs and mass production in factories.

Nicotinamide Riboside and NAD+ (nicotinamide adenine dinucleotide)
Basically, nicotinamide riboside is a naturally occurring precursor of NAD+. NAD+ is an essential metabolite in all human cells, playing a key role in cellular metabolism and energy production. What NAD does it is allows sugars, proteins, and fats to be converted into energy. Thus, this process simply shows that nicotinamide riboside boosts NAD levels in the cells of mammals to burn sugars, proteins, and fats as energy to encourage weight loss.

Nicotinamide riboside is something we have to talk about resveratrol, a compound shown to favorably alter genes that help slow the aging process in similar biochemical pathways to NR.
Mechanism of action of Nicotinamine Riboside (NR)
How does nicotinamide riboside Work? There are many different benefits of nicotinamine riboside, and each mechanism is not the same, I may explain each in detail. Generally speaking, nicotinamide riboside boots nicotinamide adenine dinucleotide (NAD+) levels higher than niacin, and uses a more efficient pathway to deliver NAD+ for use.

It all begins with the mitochondria. Mitochondria have long been known as the “power houses” of our cells, as they are responsible for energy production in each specific cell; and therefore, throughout our entire body. The below are NR benefits and mechanisms in different segments.
Nicotinamide Riboside benefits of Weight Loss

Nicotinamide riboside is able to prevent obesity by helping fight weight gain.NR boost s one’s metabolism to help burn off more calories and prevent weight gain. In a Swiss research center, they also found that mice taking nicotinamide riboside had experienced a significant amount of weight loss while being on a high-fat diet. These mice lost much more weight than the group of mice that were fed the same diet without nicotinamide riboside. It is a good choice for supplement manufacturers to use NR ingredient for their weight management products.

Nicotinamide Riboside benefits of Anti-aging/longevity

Nicotinamide Riboside promotes healthy mitochondrial function, and increase the amount of NAD+ in the cell. NAD+ is proved to be a rate-limiting co-substrate for sirtuins (also known as longevity genes). Sirtuins are enzymes known to play a key role in physiological responses to diet and exercise. Lower levels of NAD+ lead to aging in the human body. Nicotinamide Riboside can reduce free radical by-product by increasing mitochondrial efficiency. Nicotinamide Riboside’s ability to maximize NAD+ level make it unblock sirtuin active ty and thus slow down cellular aging.
Nicotinamide Riboside benefits for bodybuilding

Endurance is a great aspect in the daily bodybuilding. Energy Production is one of the biggest limiting factors of performance in any activity. With increased ATP production, Nicotinamide Riboside sets the stage for huge gains in muscle endurance.

Nicotinamide Riboside side effects

No known negative or side effects of nicotinamide riboside have been reported yet. Nicotinamide Riboside is generally regarded safe and FDA is evaluating its GRAS status.

Dosaeg of taking Nicotinamide Riboside supplements

In Cantó, et al.’s research, they supplemented the mice with a daily amount of 400 milligrams of NR per each kilogram of body mass. Translated to a human that weighs about 150 pounds, you’re looking at 28000 milligrams of NR per day, or 28 grams a day.

There is no unified recommended dose for Nicotinamide Riboside. Some supplements advise to take 250mg per serving in capsule form, and twice a day. Some suggests 100mg or 125mg per day.

Where to buy high-quality Nicotinamide Riboside ingredient?

Nicotinamide Riboside is a relatively new ingredient from Herb Nutritionals Co., Ltd and 25 kilograms stock available each month. The speculations include 99%, 98%, 90%, etc. If you want to know the price or have a reference for the certificate of analysis (COA), please contact us via mail or telephone.