Oxyresveratrol

What is oxyresveratrol?

Oxyresveratrol is comparatively a new comer to the nutritional supplement and cosmetics industry. As outlined by Wikipedia, Oxyresveratrol is a stilbenoid, in the same class of its analogs, resveratrol, pterostilbene, polydatin. It is identified in the heartwood of artocarpus lakoocha, the white mulberry and Morus alba. However, bulk oxyresveratrol is synthetic through the lab and not extracted from natural products.

Oxyresveratrol and resveratrol

We all know that resveratrol is a popular anti-aging ingredient extracted from polygonum cuspidatum and red wine. Compared with resveratrol, oxyresveratrol contains an additional hydroxyl group at position 2 of the stilbene moiety, and the oxyresveratrol structure is as below:

oxyresveratrol-structure

Oxyresveratrol is 50 times more powerful than resveratrol being a tyrosinase inhibitor. Tyrosinase is considered to be the exact enzyme in command of coloring of skin, hair, eyes in humans, animals as well as for the browning of vegetables and fruits. Oxyresveratrol exhibits a strong inhibitory impact on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis. The final results indicate that both of the number and positions of hydroxy groups in oxyresveratrol appear to play an essential role in exerting the inhibitory influence on dopa oxidase activity of mushroom tyrosinase.

Benefits of Oxyresveratrol

Oxyresvenox uncovers potential usages for being an anti-tyrosinase, anti-oxidant and anti-inflammatory component. In light of skin lightening, de-pigmentation and anti-inflammatory potential it might also be applied to cosmetic formulations by being an anti-aging ingredient.
Oxyresveratrol as an antioxidant
Oxyresveratrol showed superoxide scavenging effects, free scavenging effct and hepatoprotective effects for its antioxidant propertities. Oxyresveratrol is discovered to be a far better scavenger for 2,2-diphenyl-1-picryl-hydrazyl (DPPH, 100 microM) utilized as a common free radical model, in comparison with resveratrol or trans-4-hydroxystilbene (IC(50)=28.9, 38.5, and 39.6 microM, respectively).

Oxyresveratrol skin lightening

Oxyresveratrol, an analog of resveratrol, has long been demonstrated in experiments to possessthe most significant lightening effect. Two separate scientific studies confirmed oxyresveratrol’s skin whitening strength:

Sixty women were separated into groups and applied an evaluation sample of either licorice, kojic acid, or oxyresveratrol extract from artocarpus lakoocha on one arm. Right after no more than one month the subjects who took the oxyresveratrol displayed visible skin lightening (as opposed to the untreated arm), at the same time the kojic acid and licorice-treated participants had brightening after six and ten weeks. The oxyresveratrol produced greater lightening results than both kojic acid and licorice overallstarting from the fourth week on.

In a 1% lotion form oxyresveratrol from artocarpus lakoocha exhibited faster and greater skin bleaching than a 1% licorice lotion in a clinical studyamongst 50 women.

There are many other benefits and applications in various industries, and the below are the key summaries:
Applications:
Antioxidant
Anti-aging support
Skin lightening support
Antimicrobial support