N-Stearoylethanolamide

What is N-Stearoylethanolamide?

From Wikipedia, N-Stearoylethanolamide (SEA) is the amide of stearic acid and ethanolamine, and defined as an endocannabinoid neurotransmitter. Very little information is available with regard to the bioactivity of N-Stearoyl ethanolamide. However, the below information are summarized by our editors, and hope it may be helpful for you to know more about Stearoylethanolamide.

Generated by the PLD hydrolysis of mouse neuroblastoma cell membrane phospholipids, N-Stearoylethanolamide falls into the category of fatty N-acyl ethanolamines (aka anandamides). Abbreviated as SEA, N-stearoylethanolamine is commonly known as Stearoyl ethanolamide, Stearoylethanolamine, N-(2-hydroxyethyl)-octadecanamide,etc. 111-57-9 is SEA’s unique CAS number.

Mechanism of action of N-Stearoylethanolamide

How does N-Stearoylethanolamide work? The appetite decreasing effect of SEA was associated with a reduction in liver stearoyl-CoA desaturase-1 (SCD-1) mRNA expression. SCD-1 is the rate-limiting enzyme in the biosynthesis of monounsaturated fats and its reduction is believed to lead to increased fatty acid oxidation and decreased lipogenesis in skeletal muscle and the liver.

The Peroxisome Proliferator-Activated Receptors (PPAR) receptor family is divided into three subgroups: alpha, delta/beta, and gamma. PPARalpha is highly expressed in muscle, the liver, kidneys, and heart and is involved in the regulation of lipid metabolism, specifically the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis (storage of fatty acids).

Fat can be oxidized in the mitochondria and the peroxisomes of cells, the majority of this oxidation occurring in skeletal muscle cells and the liver. PPARalpha activation increases fat oxidation in mitochondria and peroxisomes by increasing the expression of enzymes involved in beta-oxidation of fatty acids.

In addition to this, PPARalpha activation increases the number of both peroxisomes and mitochondria. The combination of the increased number of peroxisomes and mitochondria plus the elevation in beta-oxidation of fatty acids increases the rate and capacity at which fat can be burned. The end result is more fat loss. Activation of PPARalpha would be very beneficial for any bodybuilder or fitness enthusiast looking to lose fat or watch their weight.

Functions and Benefits of N-Stearoylethanolamide supplements

Stearoylethanolamide (SEA) has been shown to decrease food intake independent of PPAR and without changing hematochemical parameters such as glucose and triglyceride levels or leptin (a hormone involved with satiety) expression.

Ingredients related with Stearoylethanolamide
Stearoylethanolamide is an N-acylethanolamine. N-acylethanolamines (NAEs) constitute a class of lipid compounds naturally present in both animal and plant membranes as constituents of the membrane-bound phospholipid, N-acylphosphatidylethanolamine (NAPE). NAPE is composed of a third fatty acid moiety linked to the amino head group of the commonly occurring membrane phospholipid, phosphatidylethanolamine. NAEs are released from NAPE by phospholipase D-type hydrolases in response to a variety of stimuli. Transient NAE release and accumulation has been attributed a variety of biological activities, including neurotransmission, membrane protection, and immunomodulation in animals. N-oleoylethanolamine is an inhibitor of the sphingolipid signaling pathway, via specific ceramidase inhibition (ceramidase converts ceramide to sphingosine). N-oleoylethanolamine blocks the effects of TNF- and arachidonic acid on intracellular Ca concentration.

Where to buy N-Stearoylethanolamide supplements?
Herb Nutritionals Co., Ltd is a genuine manufacturer of bulk quantity of raw materials of N-Stearoylethanolamide (SEA) here in China, many suppliers and trading companies are buying from us. If you need certificate of analysis(COA), pricing quotation, MSDS, specifications or other documents, please feel free to contact us via phone or email.