Trans-Pterostilbene 99%

What is pterostilbene?

Pterostilbene, as a dimethylated stilbenoid derivative of resveratrol, according to Wikipedia, belongs to the group of phytoalexins protecting plants against pathogens and infections. Dr Oz highlighted the natural ingredients pterostilbene and C3G on his Dr Oz Show on TV in Jan of 2013, making pterostilbene well-known all over the world. Many nutritional experts believe pterostilbene is better and more potent than resveratrol in various aspects. We may explore into the details step by step.
Pterostilbene Sources
There are two main sources of pterostilbene, one is from natural sources, and the other is synthetic from labs. Theoretically, pterostilbene exists in many common food and fruits, such as pterocarpus marsupium, anogeissus acuminate, rheum rhaponticum, peanuts , blueberries, cranberries and grapes. Blueberries are one of the most readily-available sources of pterostilbene and are typically available year round.

In order to achieve truly dramatic cognitive benefits from pterostilbene, food sources of pterostilbene aren’t enough. With a recommended daily dose of approximately 300 mg, you’d have to eat nearly 15,000 cups of blueberries (each cup of blueberries contains just 20 micrograms of Pterostilbene.) Supplements are an easy way to make taking the compound practical.

Blueberry extract standardized to 99% pterostilbene will be very expensive, above USD30000/KG for natural pterostilbene. Not so many nutritional manufacturers are affordable to use such expensive pterostilbene in their finished supplement formulas. Therefore, the synthetic pterostilbene ingredient is the main trend on the market, and the price is about several hundred dollars per kilo, a litter higher than the price of natural resveratrol 98%. Pterostilbene raw material from Herb Nutritionals Co., Ltd is synthetic, and the quality and price is the best on the market. All pterostilbene ingredients from China are synthetic.

Synthetic pterostilbene is nature identical, that is, it is the same as found in nature, both structurally and functionally. The main difference between synthetic pterostilbene or resveratrol and naturally-derived pterostilbene or resveratrol is the purity. Naturally derived compounds are extracted from the plants and concentrated to functional levels. During the process other naturally found and less desirable compounds are also concentrated. For example, concentrated resveratrol extracts also contain concentrated anthaquinones such as emodin which act as a natural laxative and can cause discomfort in sensitive individuals.

Synthetic pterostilbene are >99% pure, meaning that there is nothing undesirable or unknown in the pterostilbene materials.
Resveratrol VS Pterostilbene
Pterostilbene is similar in structure to the anti-aging compound resveratrol; pterostilbene contains two methoxy groups and one hydroxyl group while resveratrol has three hydroxyl groups. You may see their molecular structure comparison below.

pterostilbene and resveratrol structure comparison

However, pterostilbene is more bioavailable and preliminary research indicates that in some ways, it may be even more beneficial. We compare these two ingredients in the following aspects: absorption, bioavailability, and half life.

Pterostilbene appears to have better oral absorption and displays better metabolic stability. In other words, when you take Pterostilbene, more of it gets into your system and remains active longer. Pterostilbene with two methoxy groups and one hydroxyl group has improved lipophilicity and a higher potential for cellular uptake than resveratrol, which has three hydroxyl groups.

research suggests pterostilbene may be more powerful than resveratrol. In fact, combining pterostilbene with resveratrol may pack a potent nutritional punch, helpful for supporting healthy cellular function.

Mechanism of action of pterostilbene

Pterostilbene is the most potent stilbene, following a different mechanism of action than resveratrol. There are many benefits of pterostilbene, how does pterostilbene work? Different benefits correspond to different modes of action as well. Pharmacological actions of trans-pterostilbene include anti-inflammatory, antineoplastic and antioxidant;

Pterostilbene exhibits potent antifungal properties that are 5-10 times stronger than resveratrol. Pterostilbene also exhibits antiviral effects. The protection of the plant from various pathogens appears to be an important mechanism of stilbenes such as pterostilbene, and these protections may extend to humans and animals as well.

Pterostilbene exhibits anticancer effects via various molecular mechanisms. Studies show the actions of pterostilbene include modulation of signal transduction pathways, cell cycle regulatory genes, cell differentiation genes, oncogenes, and tumor suppressor genes.
Antioxidant activities of pterostilbene are quite different than that of resveratrol:
resveratrol (with three hydroxyl groups) neutralizes reactive oxygen species (ROS) in whole blood and isolated lymphoblasts, whereas pinosylvin (with two hydroxyl groups) influences mainly intracellular ROS; pterostilbene (with two methoxy and one hydroxyl group) reduces extracellular ROS. This localization of antioxidative effect allows the use of pterostilbene to target extracellular reactive oxygen species that are, among other things, responsible for tissue damage during chronic inflammation.
Benefits of Pterostilbene
Pterostilbene has all the benefits that resveratrol does (like antioxidants, anti-aging,and promotes longevity) , but it has much more than that. Pterostilbene is popularly known as a nootropics to enhance mental function, and also popular as a fat burner in bodybuilding supplements for its ability to fight obesity.
1. Pterostilbene as nootropics
Pterostilbene is a rising star as a common ingredient in many pre workouts supplements. As a nootropic, pterostilbene helps relax the mind and enhance cognition. It’s also often formulated in pre-workouts due to its ability to help vasodilate the blood vessels, thereby offering similar effects to other nitric oxide promoting ingredients.

2.Pterostilbene and Obesity
The pterostilbene obesity research was focused on seeing what type of effects this compound would have in animals, particularly rats. The study, called “Pterostilbene, a Dimethyl Ether Derivative of Resveratrol, Reduces Fat Accumulation in Rats Fed an Obesogenic Diet” and published recently, shows that there is indeed a correlation between this compound and weight loss, as had been suggested before. The authors believed Pterostilbene was able to affect levels of fat mass due to its ability to reduce lipogenesis or the creation of extra fat in fat cells as well as increase fat oxidation or fat burning in the liver.
3. Pterostilbene Promotes Longevity
Trans-pterostilbene is a bioactive chemical which has been shown to reverse cognitive decline, stabilize blood sugar, and reduce inflammation. In vitro and in vivo studies support pterostilbene’s therapeutic and preventative effects. The compound also acts as a caloric restriction mimetic, triggering the human body to release biochemicals such as adiponectin which slows aging and promotes healing.
Pterostilbene Side Effects
No serious side effects of pterostilbene are reported during the past years, and there are no much information regarding side effects on the internet since it is still relatively new to the dietary supplement industry. Of course, never dose too much each time. 300mg is said to be safe each day.

Pterostilbene Dosage
Pterostilbene is relatively new to the market, and there has yet to be an established recommended Daily Intake (RDI) for pterostilbene. In vitro human science and clinical studies suggest that a daily dose of 100mg to 250mg is recommended. A single 50mg to 125mg capsule twice a day is for all adults. If combined with other ingredients such as resveratrol, the amount may be lower accordingly.

Where to buy pterostilbene
Herb Nutritionals co., Ltd is the manufacturer and supplier of bulk raw materials of pterostilbene in China. Our synthetic resveratrol and pterostilbene are commonly used in dietary supplement formulas. Pterostilbene is one of our relatively new ingredients. Documents like certificate of analysis (COA), specification sheet. MSDS, manufacturing declaration, nutritional information, Non-Allergen Declaration, Non-Irradiation declaration, Non-TSE/BSE/GMO declaration, Non-Pesticide/Herbicide declaration of pterostilbene are all available upon your request.