L-theanine 99% CAS 3081-61-6

L-theanine is a nootropic to relieve anxiety,stress, enhance brain health.


Product name L-theanine 99%
source Green tea extract/enzymatic synthesis/enzymatic synthesis
Latin name Camellia sinensis O. Ktze.
CAS number 3081-61-6
Active ingredient L-theanine
CAS number 3081-61-6
Synonyms 5-N-Ethyl-L-glutamine;
L-Glutamic acid-γ-monoethylamide,Suntheanine, L-TeaActive
Molecular Formula C7H14N2O3
Molecular weight 174.19766
Specifications/assay 98%,99%
Appearance/color White crystalline powder
Taste and odor Slight sweet with no odor
Solubility Soluble in water
Appearance in solution Transparent, colorless
package 25kg/drum
capacity 400 tons/year
Benefits Relieve anxiety,stress, enhance brain health.
Application Supplements,food,drinks,beverages
Dosage 250mg/serving

What is L-theanine?

L-theanine is an active ingredient highly concentrated in the leaves of green tea plant (camellia sinensis). L-theannine

L-theanine, a GRAS-approved ingredient, has many other names, such as Gamma-glutamylethylamide(L-γ-glutamylethylamide), L-Glutamic acid-γ-monoethylamide and 5-N-Ethyl-L-glutamine. 3081-61-6 is its unique identity of Chemical Abstracts Service (CAS) number with molecular formula C7H14N2O3, and its chemical structure is as below:


L-theanine is a popular nootropic good for stress, sleep, and often used together with melatonin, phenibut, caffeine,etc. In addition to its application as supplements, l-theanine is also applied in drinks, beverages, bars, chews, teas, etc.

Sources of L-theanine

L-theanine source

L-theanine source

Generally speaking, there are three ways to get theanine:
1. natural extract from green tea extract;
2. enzymatic synthesis;
3. and chemical synthesis from food grade L-glutamic acid and ethylamine using purified water and ethanol as solvent.

L-theanine from the three methods above is all safe and passes the GRAS status (generally regarded as safe) by the FDA. Wikipedia has mentioned that L-theanine may be also found from mushroom Xerocomus badius, but it has never been bulk manufactured.

Of course, synthetic L-theanine is much cheaper than natural extracted source. If you want to know the various pricing, please email us with specific quantity and shipping desitnation.

Mechanism of action of L-theanine

So how exactly does L-theanine work? As a natural nootropic, L-theanine crosses the bloodstream-brain barrier. L-Theanine has got the capacity to imitate the functionality of glutamate, a naturally sourced bodily amino acidity which helps within the transmission of nerve impulses within the brain. L-theanine increases dopamine and serotonin production within the brain, creating a feeling of relaxation.

When L-theanine crosses the bloodstream-brain barrier, it makes its way into the nervous system and targets a variety of chemicals like Serotonin, Dopamine, Gamma aminobutyric acid, and Norepinephrine. They are all effective brain chemicals which have many effects upon cognitive processes, sleep and relaxation cycles, as well as pleasure and also the brain’s reward system.

Furthermore, L-Theanine has shown an ability to increase amounts of dopamine and serotonin within the brain through the nervous system, and contains a low affinity for NMDA, AMPA, and kainite receptors.

Benefits of L-theanine

L-theanine has proven in clinical trials to be beneficial to relieving the symptoms of mental stress, physical stress, anxiety, depression, etc. In addition, L-theanine enahces brain health and mood, such as nerve protection, alertness, cognitive performance and improves learning ability, etc. And it is often sell and buy as a nootropics in UK, Germany, Poland, Italy, Spain, Canada, USA, etc.

L-Theanine for Anxiety

L-theanine anxiety

L-theanine anxiety

L-theanine functions as a nootropic by supplying a rise in performance and a focus while still serving as a calming aging. Much like L-Tryptophan in structure, L-Theanine is really a glutamine analog that also creates alpha brain waves. They are electric impulses within the mind which accompany states of deep relaxation and mental focus. Their presence can regulate the over-activity of beta waves, which prompts feelings of hyper alert wakefulness. An excess of beta waves can make the feeling of anxiety and stress. Taking L-Theanine for depression, general panic attacks or social anxiety will keep individuals beta waves under control.

L-Theanine Stress & Mood

L-theanine for stress

L-theanine for stress

It’s been reported that about 65 % from the adult population in US encounters some type of stress, which IS constantly rising. Clinical research indicates that fifty mg – 200 mg L-theanine naturally encourages activity within the brain referred to as alpha waves that are connected having a relaxed but alert state of mind.

L-Theanine is definitely an anxiety reducer and mood Enhancer that Increases alpha Waves and mental performance.Studies have shown that L-theanine reduces stress, enhances sleep quality, reduces signs and symptoms of premenstrual syndrome or pms, raises mental skill, and reduces negative unwanted effects of caffeine. These clinical effects are proportional to L-theanine’s capability to stimulate producing alpha brain waves (frequently accomplished by meditation and indicated by relaxation with greater mental focus and mental performance), in addition to reduced beta waves (connected with anxiety, scattered ideas, and adhd).

L-Theanine for brain health

L-theanine brain health

L-theanine brain health

A growing body of research suggests that theanine may be a powerful tool in boosting cognitive function. L-Theanine has been proved to assist brain chemicals that positively affect learning and memory.

A 2010 study Nutritional Neuroscience signifies that a mixture of theanine and caffeine may help improve cognitive performance. For the study, 44 teens needed whether placebo or a mixture of theanine and caffeine right before undertaking a demanding cognitive task. Researchers learned that the mix of theanine and caffeine substantially enhanced precision and gratifaction and aided to enhance focus while undertaking the task.

Ample evidence proves L-theanine works together caffeine to negate the undesirable effects while growing the benefits. Anxiety and jitters triggered by caffeine are reduced by L-theanine supplementation.

L-theanine side effects

L-theanine as a food supplement has not reported with serious side effects yet. Individuals who are taking theanine never complained about any adverse effects on their health. There are no known specific side effects associated with L-theanine.

L-theanine dosage

The dosage for L-theanine is unanimously the same as 250mg per serving, according to the instructions from most of the supplements containing L-theanine. It may vary with the age, gender, and the purposes of taking it.

Where to buy bulk L-theanine powder

L-theanine is available from natural green tea extract and synthetic from chemicals or enzymatic action. All the three sources are available from Herb Nutritionals. However, most of our clients prefer the chemical-synthesized L-theanine since it is cheaper and still has the same effects as the natural ones. If you want to know more about bulk L-theanine pricing, COA, comparisons, please don’t hesitate to let us know via mail or direct phone.